Non-steroidal anti-inflammatory drug (NSAID) that acts through selective inhibition of the cyclooxygenase-2 (COX-2) enzyme, which mediates prostaglandin synthesis. COX-2 is the main isoenzyme responsible for prostaglandin production associated with pain, inflammation, and fever. In in vitro studies conducted using whole canine blood, firocoxib demonstrated approximately 380-fold greater selectivity for COX-2 compared to COX-1.
Veterinary use
Box containing 10 pipettes of 0.67 mL
Box containing 10 pipettes of 1.34 mL
Box containing 10 pipettes of 2.68 mL
Box containing 10 pipettes of 4.02 mL
Each 100 mL contains:
Fipronil: 10 g
(S)-methoprene: 9 g
Excipients: q.s. to 100 mL.
Route of administration: Topical.
In case of accidental ingestion, induce vomiting and seek immediate medical attention.
Symptoms of intoxication:
They are not product-specific; however, neurological signs such as tremors and excessive sedation may occur. In case of dog intoxication, immediately consult a veterinarian. No specific antidote is known.
Warnings and precautions:
For external veterinary use in dogs only.
As with all topical ectoparasiticide treatments, avoid contact of the product with fingers; wash hands thoroughly with soap and water after application.
Do not smoke, eat, or drink during application.
Do not handle treated animals until the coat is completely dry.
Keep out of reach of children and domestic animals.
Do not reuse the container; dispose of it safely after use.
Do not store with food products.
Dosage and directions for use:
Apply one pipette according to the dog’s body weight, as follows:
Size S: 1 pipette of 0.67 mL per dog weighing up to 10 kg.
Size M: 1 pipette of 1.34 mL per dog weighing 11 to 20 kg.
Size L: 1 pipette of 2.68 mL per dog weighing 21 to 40 kg.
Size XL: 1 pipette of 4.02 mL per dog weighing 41 to 60 kg.
Indicated for the treatment and control of infestations by fleas (Ctenocephalides felis), ticks (Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus and Dermacentor variabilis), and lice (Trichodectes canis) in dogs.
The use of FRONTLINE Combo® is recommended as adjunct therapy in the management of flea allergy dermatitis (FAD). In such cases, monthly application is advised, along with treatment of all animals in contact with the affected dog.
FRONTLINE Combo® eliminates adult fleas before egg laying and helps control reinfestation. Its persistent activity provides control of fleas, lice, and ticks for up to 1 month.
Additionally, the product not only eliminates adult fleas but also inhibits the development of eggs, larvae, and pupae from fleas acquired for up to 1 month after application.
